Laboratorio de Enzimología


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Dra. Leonor Thomson


Cabrera, M.; Lavaggi, M.L.; Croce, F.; Celano, L.; Thomson, L.; Fernández, M.; Pintos, C.; Raymondo, S.; Bollati, M.; Monge, A.; López de Ceráin, L.; Piro, O.E.; Cerecetto, H.; and González, M. Identification of chalcones as in vivo liver monofunctional phase II enzymes inducers. Bioorganic. Med. Chem. 18(14):5391-9, 2010.

Trujillo, M.; Alvarez, B; Souza, JM; Romero, N; Castro, L; Thomson, L and Radi, R. Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration. In: Nitric Oxide. Biology and Pathobiology (2nd edition) Edited by: Louis J. Ignarro. Elsevier, Inc. Pp. 1010-1050, 2009.

Boiani, M; Tortora, V; Thomson, L; y Denicola, A. Mecanismo de acción tripanocida del Nifurtimox ¿es realmente vía estrés oxidativo? Publicado en: A 100 años del descubrimiento de la enfermedad de Chagas. Contribuciones desde Uruguay. Editoras: Dras. Beatriz Garat y Adriana Parodi-Taliche. Organización Panamericana de la Salud, 2009.

Denicola, A; Alvarez, B; and Thomson, L. 3-nitrotyrosine, a post-translational modification associated with nitroxidative stress. In: Free Radical Pathophysiology. Transworld Research Network (S. Alvarez, and P. Evelson, Editors) pp 39-55, 2008.

Parastatidis I, Thomson L, Burke, A, Chernysh, I, Nagaswami, C, Visser, J, Stamer, S, Liebler, DC, Koliakos, G, Heijnen, HFG, FitzGerald, G, Weisel, JW, and Ischiropoulos, H. Fibrinogen b-chain tyrosine nitration is a prothrombotic risk factor. J Biol Chem. 283:33846-53, 2008.

Trujillo, M.; Ferrer-Sueta, G., Thomson, L., Flohé, L., and Radi, R. Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. Subcell Biochem., 44:83-113, 2007.

Parastatidis I, Thomson L, Fries DM, Moore R, Tohyama J, Fu X, Hazen SL, Heijnen HF, Dennehy MK, Liebler DC, Rader DJ, and Ischiropoulos H. Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I-deficient mice. Circ. Res., 101: 1- 9. 2007.

Thomson L, Christie J, Vanseth C, Lanken PN, Fu X, Hazen SL, and Ischiropoulos H. Identification of immunoglobulins that recognize 3-nitrotyrosine in patients with trauma and acute lung injury. Am. J. Respir. Cell Mol. Biol., 36:152-157, 2006.

Meulener MC, Xu K, Thomson L, Ischiropoulos H, and Bonini NM. Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci USA, 103: 12517-12522, 2006.

Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, Regan EA, Crapo J, Ischiropoulos H. Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radic Biol Med.; 40:1903-1913; 2006.

Aguirre G, Boiani L, Cerecetto H, Di Maio R, Gonzalez M, Porcal W, Denicola A, Moller M, Thomson L, Tortora V. Benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives as potential antitrypanosomal drugs. Part 3: Substituents-clustering methodology in the search for new active compounds. Bioorg Med Chem.;13:6324-35 2005.

Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H, Smith JD, Kinter M, Hazen SL. Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest. 114:529-41; 2004.

Vadseth C, Souza JM, Thomson L, Seagraves A, Nagaswami C, Scheiner T, Torbet J, Vilaire G, Bennett JS, Murciano JC, Muzykantov V, Penn MS, Hazen SL, Weisel JW, Ischiropoulos H. Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. J Biol Chem. 279:8820-6; 2004.

Thomson, L.; Denicola, A.; and Radi, R. Protective role of Trypanosoma cruzi thiols against peroxynitrite-mediated cytotoxicity. Arch. Biochem. Biophys.. 412:55-64; 2003.

Cassina, A. M.; Hodara, R.; Souza, J. M.; Thomson, L.; Castro, L.; Ischiropoulos, H.; Freeman, B. A.; and Radi, R. Cytochrome c nitration by peroxynitrite. J. Biol. Chem. 275: 21409-15; 2000.

Thomson, L.; Gadelha, F.R.; Peluffo, G.; Vercesi, A.E.; and Radi, R. Peroxynitrite affects Ca2+-transport in Trypanosoma cruzi. Molec. Biochem. Parasitol. 98: 81-91; 1999.

Radi, R. Navilliat, M.; Thomson, L.; Peluffo, G.; Quijano, C.; Alvarez, M. N.; Alvarez, B.; Ferrer, G.; Castro, L.; Cassina, A. M.; Trujillo, M.; Piacenza, L.; Rubbo, H.; y Denicola, A. Nitric oxide and peroxynitrite in immunoprotection and immunopathogenia of Chagas disease. Boletín de la Red de Investigación y Entrenamiento en Enfermedades Parasitarias del Cono Sur de América Latina. pp. 40-41; 1998.

Radi, R.; Castro, L.; Rodríguez, M.; Cassina, A; and Thomson, L. Free radical damage to mitochondria. In: Mitochondria & Free Radicals in Neurodegenerative Diseases. (Beal, M.F., Howell, N., and Bódis-Wollner, I., eds.) 57-89, Wiley-Liss, Inc., 1997.

Gadelha, F. R., Thomson, L.; Fagian, M. M.; Costa, A. D. T.; Radi, R.; and Vercesi, A. E. Ca2+-independent permeabilization of the inner mitochondrial membrane by peroxynitrite is mediated by membrane protein thiol cross linking and lipid peroxidation. Arch. Biochem. Biophys. 345: 243-250, 1997.

Thomson, L., Trujillo, M., Telleri, R., and Radi, R.. Kinetics of cytochrome c2+ oxidation by peroxynitrite: implications for superoxide measurements in nitric oxide-producing biological systems. Arch. Bioch. Biophys. 319: 491-497, 1995. 

Radi, R.; Denicola, A.; Navillat, M.; Peluffo, G.; Rubbo, R.; Thomson, L. and Rodríguez, D. A proposal for an immunoprotective and immunopathogenic role of peroxynitrite in Chagas’disease. In: “Biology of Parasitism” (Ehrlich, R. & Nieto, A. Eds.) pp. 41-51, 1994.

Radi, R.; Thomson, L.; Rubbo, H. and E. Prodanov. Cytochrome c-catalyzed oxidation of organic molecules by hydrogen peroxide. Arch. Bioch. Biophys. 288: 112-117, 1991.

Radi, R.; Rubbo, H.; Thomson, L. and E. Prodanov. Luminol chemiluminescence using xanthine and hypoxanthine as xanthine oxidase substrates. Free Rad. Biol. Med. 8: 121-126, 1990.